The obtained pattern was quite similar to the one that did include HCs, both regarding the weak separation between CHD-PAH and the other three PH subgroups (Fig. 5a; compare with Fig. 4a) and the inflammatory mediators that contributed most to Dim1 and Dim2 (Additional file 1: Fig. 4A; compare with Fig. 4b). Here, TXNL4B is linked to pulmonary arterial hypertension.