The study cohort consists of 25,186 patients (mean age = 63.0, interquartile range [IQR] of age = 15.1 years, male = 50.4%, type 1 diabetes mellitus = 7.37%, baseline diabetes duration = 2.84 ± 2.54 years, total duration = 69,332 patient-years, daily insulin dosage: 20.2 ± 12.6 units). The gene discussed is INS; the disease is diabetes mellitus.