TJP1 and infectious otitis media: Tight junctions, as part of the gut barrier composition, connect adjacent IECs and regulate gut permeability.35 We found that zona occludens 1 (ZO-1) was expressed at a lower level in both the non-neoplastic and neoplastic colon tissue of the Zfp90fl/fl mice treated with AOM-DSS compared with that in the Zfp90ΔIEC mice (Figure 2(d, e).