Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that the genes differentially expressed between the Zfp90fl/fl and Zfp90ΔIEC mice could be categorized into 27 pathways related to the immune system, signal transduction, and cancers (Supplementary SFigure 2e), such as the “Cytokine-cytokine receptor interaction”, “Inflammatory bowel disease (IBD)” and “NF-κB signaling pathway”. The gene discussed is NFKB1; the disease is cancer.