According to our previous study,32 a SNP residing in the intron of CDH1 (encoding cadherin 1) could mediate a long-range regulation on ZFP90. Therefore, we could not exclude the possibility that the expression of CDH1 might also be regulated by ZFP90 because of their proximity, and such modulation might mediate the protective role of ZFP90 deletion, considering the importance of CDH1 in IBD and CRC.33,34 We thus tested the expression level of CDH1 in naïve and AOM-DSS-treated Zfp90fl/fl and Zfp90ΔIEC mice. Here, CDH1 is linked to infectious otitis media.