Genes encoding proteins of the desmosome have also been proposed to be relevant for DCM,37 and DSP, DSG2, and PKP2, considered definitive when curating an ARVC phenotype strictly defined by the Task Force criteria,38 had various degrees of evidence when curated strictly for DCM.15 In the case of DCM, DSP was scored as strong and may likely move to a definitive classification in future re-evaluation. The gene discussed is DSG2; the disease is familial dilated cardiomyopathy.