This was an anticipated finding that provided robust support of pathogenicity because it has been well established that TTN alterations of this type are overrepresented in individuals with DCM.28–32 Given the complexity of TTN variant architecture and the broad contribution of TTN variation in DCM beyond the A band represented in our data curation from the published literature, future TTN domain- and band-specific curations integrated with expression data should be considered. Here, TTN is linked to familial dilated cardiomyopathy.