PTPN1 knockdown led to increased tumor properties (cell growth, invasion, and migration) and increased pSrc<sup>Tyr416</sup> expression in bladder cancer cells, suggesting that the miR-130 family upregulates multiple RTK signaling by targeting PTPN1 and subsequent Src activation in bladder cancer. This evidence concerns the gene PTPN1 and urinary bladder carcinoma.