PVT1 and renal cell carcinoma: Ren et al. [77] identified the functional connection of PVT1 with miR-16-5p, as the silencing of this miRNA has led to the reversion of the regulatory effect on RCC cells induced by the downregulation of PVT1. An in-silico target prediction showed that miR-16-5p is a target of PVT1. Thus, its levels decrease as a result of binding to PVT1 (Figure 1).