HMGB1 and cancer: The ability of CGs to cause CALR plasma membrane exposure and ATP and HMGB-1 release from cells to the extracellular area was further confirmed in a panel of human cancer cell lines, particularly cells from the cervix (HeLa), breast (MDA-MB 231), and colon adenocarcinoma (HCT 116), non–small-cell lung (A549), prostate (LNCaP), oral squamous (Cal27), and hepatocellular carcinoma (HepG2).