NFE2L2 and breast carcinoma: Therefore, in our previous study, we examined how oxidative challenge (known contributor to breast carcinogenesis and a mechanism of effective anticancer therapy too [101]) affects lipid profile, levels of oxidative stress mediators and NRF2, the expression pattern of AQP1, AQP3, AQP5, and sensitivity to H2O2 in three breast cancer cell lines (representing hormone-positive (MCF-7), HER2-positive (SkBr-3) and TNBC (SUM 159)) [95].