In lung cancer stem cells AQP3 silencing caused upregulation of Wnt/glycogen synthase kinase-3β (GSK-3β)/β-catenin pathway implying its role in reducing the activity of this signalling pathway and, thereby, inhibiting apoptosis and reducing differentiation of lung cancer cells keeping stemness of these cell [46]. The gene discussed is GSK3B; the disease is lung carcinoma.