NFE2L2 and breast cancer: In breast cancer cell lines, MCF7, SUM159 and SkBr3, AQP3 was the most expressed aquaporin, and in HER2 positive cells it was upregulated together with NRF2 by H2O2 [95] implying for then need to study effects of AQP3 overexpression in relation to the parts of antioxidative system.