AGT and sarcopenia: The renin–angiotensin system (RAS) is strongly implicated in maintaining muscle function, and one of the peptide products of this system, angiotensin II, targets skeletal muscle cells via the AT1R receptor and has been implicated in the development of sarcopenia [115], both directly through AT1R, which results in increased resistance to insulin and IGF-1, and indirectly by increased production of myostatin, glucocorticoids, TNF-α, and IL-6.