GLS and neoplasm: Furthermore, a new first-in-class orally bioavailable glutaminase inhibitor (CB-839), which inhibits glutathione production and blocks tumor glutamine consumption, is in early phase clinical trials as monotherapy or in combination for select tumors; examples include colorectal cancer (ClinicalTrials.gov Identifier: NCT02861300), non-small cell lung cancer (ClinicalTrials.gov Identifier: NCT04250545), hematological malignancy (ClinicalTrials.gov Identifier: NCT03047993), brain cancer (ClinicalTrials.gov Identifier: NCT03528642), and so on.