Furthermore, a stable expression of CA-STAT3 in Huh7 cells partly, but significantly, alleviated HsA-mediated cytotoxicity, as compared to recombinant Huh7 cells expressing mock plasmid (Figure 4f), suggesting that HsA exhibits cytotoxicity of HCC cells via the downregulation of STAT3. The gene discussed is STAT3; the disease is hepatocellular carcinoma.