Indeed, HDL from SLE patients failed to promote the synthesis and translocation of the nuclear factor ATF3, resulting in NF-κB activation and inflammatory cytokine production in macrophages [46]; this effect is mediated by the ability of oxidized HDL to bind lectin-like oxidized LDL receptor 1 (LOX1). The gene discussed is OLR1; the disease is systemic lupus erythematosus.