AKT1 and non-small cell lung carcinoma: Its possible mechanism might be that IOPS inhibits NF-κB nuclear translocation and JNK/AKT phosphorylation in A549 cells, and inhibits the AKT/NF-κB signaling pathway that reduces the expression level of matrix metalloproteinases (MMP); therefore, the invasion of human non-small cell lung cancer A549 cells was inhibited [96,97].