Germline variants in DDR genes (e.g., the double-strand break genes, BRCA1, BRCA2, ATM, ATR, NBN, CHEK2, PALB2, and RAD51D, and the mismatch repair genes MLH1, MSH2, MSH6, and PMS2) are associated with an increased risk for PCa (early onset, aggressive or metastatic disease) [17,18,19,20]. Here, MSH2 is linked to posterior cortical atrophy.