IL6 and systemic lupus erythematosus: SLE monocytes also have an altered phenotype and function: an increased expression of adhesion molecules [25], Fc receptors for IgG and co-stimulatory proteins, and a dysregulated cytokine secretion (decreased production of IL-1 [26] but an increased production of TNF-α [27], IL-6 [28] and IL-10 [12,13]).