A recent study found that the TRAF-interacting protein with a forkhead-associated domain B (TIFAB), which is a signaling protein in hematopoietic and immune cells, binds to and increases the catalytic activity of USP15, resulting in the enhanced deubiquitination and stabilization of MDM2 and consequent inhibition of the tumor-suppressive activity of p53 [80]. The gene discussed is USP15; the disease is neoplasm.