To explain the disparate findings, Youssef and Badr (2011) [163] put forward three postulations: (i) off-target effects of PPAR ligands, (ii) diverse pharmacokinetic properties of PPAR agonists, and (iii) cancer stage-dependent effect, of which the first two focus on the intrinsic characteristics of the synthetic PPAR ligands while the last one is linked to the biological context of the TME. Here, PPARA is linked to cancer.