In addition, recent data evidenced a down-regulation of miR-125b levels in SSc skin and fibroblast [68], and an altered expression of miR-150-5p, miR-16-5p, and miR-485-5p was found in peripheral blood mononuclear cells (PBMCs) of SSc patients, which negatively correlated with survivin mRNA expression [69]. This evidence concerns the gene BIRC5 and systemic sclerosis.