Clues of a possible HCMV involvement in SSc include the detection of HCMV transcripts in ECs from the skin of SSc patients [26], the presence of significantly higher levels of anti-HCMV antibodies in SSc subjects compared to controls [27,28,29,30], the possible role of the above antibodies in recognizing fibroblasts and EC surface antigens, evoking molecular mimicry [31,32], and the presence of specific anti-HCMV CD8+ T cells in SSc patients, associated with the disease severity [15]. This evidence concerns the gene CD8A and systemic sclerosis.