In fact, besides predictable pathways associated with altered cell cycle, transcription, proliferation, and apoptosis, infection by HCMV and HHV-6A also was associated with activation of signaling pathways specifically correlated with induction of fibrosis, including signaling through Wingless/Int (WNT), transforming growth factor (TGF)-β, and β-catenin, whose cross-talk has been recognized as one of the major trigger of fibrotic process. This evidence concerns the gene TGFB1 and infection.