In this regard, a recent study used combinations of DNA methyltransferase inhibitors with anti-TIGIT or anti-killer cell lectin-like receptor subfamily G member 1 antibodies and were able to reduce the formation of the tumor-exposed NK cell phenotype, an NK cell phenotype that is unable to promote tumor killing and is responsible for promoting cancer metastasis [96]. The gene discussed is KLRG1; the disease is neoplasm.