Mutations in lipid-producing enzymes, such as GBA, associated with familial PD and SNPs in multiple PD related-genes involved in lipid homeostasis [7,8,9,10,11] (SREBF1, ASAH1, SMPD1, PLA2G6, amongst others) have been linked to PD. This evidence concerns the gene SMPD1 and Parkinson disease.