SHMT2 and cancer: Increased glycine consumption and expression of enzymes involved in the mitochondrial glycine biosynthesis pathway, such as mitochondrial serine hydroxymethyltransferase 2 (SHMT2), methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), and MTHFD1-like (MTHFD1L), are associated with higher rates of growth and proliferation in cancer cells [111].