MTOR and cancer: Mammalian Target Of Rapamycin Kinase (mTOR) mutations, such as mutations located in FRB-domain, as well as mutation located in kinase domain, are responsible for resistance to rapamycin analogs (rapalogs, e.g., temsirolimus, everolimus that are first in class mTOR kinase inhibitors approved for cancer therapy [162]) and second generation mTOR ATP competitive inhibitors (TORKi), respectively [163].