Progesterone also augmented the anti-tumour effects of vitamin D by upregulating the expression of the vitamin D receptor in EC cells [174], whilst simultaneous administration of a metabolically active form of vitamin D (1,25-dihydroxyvitamin D3) and progesterone led to a significant upregulation of proteins that help restrain tumour growth and metastasis in EC cells [175]. The gene discussed is VDR; the disease is neoplasm.