As the results of a preclinical study suggested that ALL cells were dependent on both BCL-2 and BCL-XL, navitoclax (a BCL-2 and BCL-XL inhibitor) was tested in combination with venetoclax and chemotherapy for pediatric and adult patients with relapsed/refractory ALL or lymphoblastic lymphoma [114]. Here, BCL2 is linked to acute lymphoblastic leukemia.