Genetic abnormalities newly identified by comprehensive genomic analyses include BCR/ABL1-like ALL (Ph-like ALL), intrachromosomal amplification of chromosome 21 (iAMP21), DUX4-rearranged ALL, ZNF384-rearranged ALL, MEF2D-rearranged ALL, PAX5-altered (PAX5alt) ALL, NUTM1-rearranged ALL, and ETV6/RUNX1-like ALL. This evidence concerns the gene DUX4 and acute lymphoblastic leukemia.