A phase 2 international study of anti-CD19 CAR T cells (tisagenlecleucel) in pediatric and young adult patients with relapsed/refractory B-ALL showed a complete remission rate of 81% at 3 months and EFS and OS of 73% and 90%, respectively, at 6 months [137]. Here, CD19 is linked to precursor B-cell acute lymphoblastic leukemia.