BCR and diffuse large B-cell lymphoma: For instance, a comparison of the genetic signatures across DLBCLs using genome-wide arrays and multiple clustering algorithms captured tumor-intrinsic distinctions in three clusters [19] (a) B-cell receptor (BCR) /proliferation cluster (BCR-DLBCL) displaying up-regulation of genes encoding BCR signaling components, (b) the oxidative phosphorylation cluster (OXPHOS DLBCL), and (c) the host response cluster (HR).