(Over)expression of HK2 is also linked to tumor progression and/or metastasis in a variety of diverse neoplastic models (Table 1) including HCC [62], colorectal carcinoma [54], lung cancer, breast cancer [15], prostate cancer [58,63,64], diffuse large B-cell lymphoma [65] and glioblastoma [66]. This evidence concerns the gene HK2 and prostate cancer.