Furthermore, during the process of hepatocarcinogenesis hexokinase expression can switch from isozyme HK4 to HK2, making hepatocellular carcinoma (HCC) cells insensitive to the anti-neoplastic activity of Natural Killer (NK) cells [45], even if the mechanisms underlying this regulation of innate immunity remain to be elucidated. This evidence concerns the gene HK2 and hepatocellular carcinoma.