In addition to its role in age-dependent intestinal barrier homeostasis and defense against oral bacterial infection, the JAK/STAT pathway functions in antiviral immunity, particularly in response to infection with the RNA viruses Drosophila C Virus (DCV) and Cricket paralysis virus (CrPV) [20,56], as well as the DNA virus Invertebrate iridescent Virus 6 (IIV-6) [57]. This evidence concerns the gene SOAT1 and infection.