To characterize RBC adhesive potential after treatment of RRx-001, we utilized an in vitro HUVEC assay under hypoxic conditions with administration of either LPS or TNFα to mimic the hypoxia and cytokine mediated inflammation known to characterize the tumor microenvironment and induce endothelial phosphatidylserine receptor expression [17,19,20]. The gene discussed is TNF; the disease is neoplasm.