To characterize RBC adhesive potential after treatment of RRx-001, we utilized an in vitro HUVEC assay under hypoxic conditions with administration of either LPS or TNFα to mimic the hypoxia and cytokine mediated inflammation known to characterize the tumor microenvironment and induce endothelial phosphatidylserine receptor expression [17,19,20]. This evidence concerns the gene JMJD6 and neoplasm.