Hypoxia-induced secreted exosomes released from cancer cells contain plasma membrane receptors, including glucose transporter, EGFR, P-glycoprotein, and multidrug resistance protein 1; angiogenic proteins, such as VEGF, FGF, and angiogenin; and various noncoding RNAs, including miRNAs and lncRNAs [34,37,38]. Here, VEGFA is linked to cancer.