Since hypoxic stress leads to significant alterations in the molecular content and function of exosomes, hypoxic tumor-derived exosomes transfer some target genes, including glucose transporter, epidermal growth factor receptor (EGFR), transfer receptors, and P-glycoprotein, to non-hypoxic cells, resulting in the internalization of receptors and clustering of oncogene/proto-oncogene-activating receptors [10]. The gene discussed is EGFR; the disease is neoplasm.