To further determine whether hypoxia-induced exosomes isolated from drug-resistant CRCs affect CRC progression and co-administration of 5FU and anti-PrP antibody suppresses CRC progression in SNU-C5/WT cells pretreated with an exosomes xenograft model (Figure 7A), we assessed the tumor size in SNU-C5/WT cells pretreated with an exosomes xenograft model after treatment with H-5FUR-Exo + PBS, H-5FUR-Exo + 5FU, H-5FUR-Exo + 5FU + anti-PrP antibody, or H-5FUR-Exo + anti-PrP antibody (Figure 7B). Here, PRNP is linked to colorectal carcinoma.