In HUVECs containing Dil-labeled 5FUR exosomes, H-5FUR-Exo significantly increased the level of PrPC compared with N-5FUR-Exo and si-PRNP + H-5FUR-Exo (Figure S9C), suggesting that PrPC in exosomes isolated from CRC cells is transferred into endothelial cells. Here, PRNP is linked to colorectal carcinoma.