Of note, it has been shown that aggressive tumors, such as metastatic PC, cleave MICA/B from the membrane of NK and CD8+ T cells, release the soluble form (sMIC) into the plasma, and downregulate the NKG2D receptor from the immune cells, thereby promoting immune suppression and tumor escape [95,96,97]. Here, MICA is linked to pachyonychia congenita.