Moreover, several proteins (ANO6, PLD1, ARSA, MPO and CPNE3) of the neutrophil degranulation cluster upregulated in PRE-R patients, with the exception of ARSA, were also found to be regulated in the paired sample study with AML cells derived at both first diagnosis and first relapse time points and in the high-risk vs. low-risk comparison (Figure S5b and S5c) [71]. This evidence concerns the gene ARSA and acute myeloid leukemia.