While rare in OGDH, whole-exome sequencing and rare variant burden analysis determined an overabundance of putative, potentially damaging mutations in the OGDHL (OGDH-like) and DHTKD1 genes across multiple patients with eosinophilic esophagitis (EoE), a chronic allergic disorder that presents in infancy and in adulthood [6]. Here, DHTKD1 is linked to eosinophilic esophagitis.