In addition, the cancer-promoting proteins, TMEM207 (transmembrane protein 207) and VOPP1 (vesicular overexpressed in cancer pro-survival protein 1), found overexpressed in various cancers, bind to WWOX and inhibit its tumor-suppressor activity not by inhibiting its expression but its ability to associate with some protein partners [14,69,107]. This evidence concerns the gene WWOX and cancer.