Ectopic expression of WWOX in different osteosarcoma cell lines inhibits metastasis, and the expression of RUNX2 and its target genes such as VEGF (vascular endothelial growth factor gene) involved in angiogenesis and MMP13 (matrix metalloproteinase-13 gene) involved in invasion [81]. The gene discussed is VEGFA; the disease is osteosarcoma.