Astrogliosis has been detected in ALS/FTLD TDP-43 mouse models including those expressing the human TDP-43 p.A315T and p.M337V proteins [196,197], overexpression of mouse TDP-43 in the forebrain [198] and overexpression of human TDP-43 in neurons [199]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.