Among those, 11 patients had arthritis, 9 flares, and 2 of new-onset, and in 8/11 patients, arthritis was the only presentation without extra-articular features, 7 cases of arthritis were seronegative inflammatory arthritis and 3 were anti-citrullinated protein antibody positive (ACPA+), rheumatoid factor positive (RF+) autoimmune and 1 case of mixed pattern nature (Figure 1). This evidence concerns the gene PRTN3 and arthritic joint disease.