Herein, we report a wide variety of vaccine-associated flares or new-onset in IMDs ranging from autoinflammatory, mixed pattern disease (BD) and autoimmune diseases rather than an enrichment in autoimmune diseases that are linked to disordered nucleic acid metabolism and abnormal interferon-stimulated gene signatures involving the TLR-7/9 pathways [43]. This evidence concerns the gene TLR7 and Behcet disease.