Several studies showed that the other CCN family member, connective tissue growth factor (CTGF/CCN2), facilitates liver fibrosis in humans and animal models [29,30], whereas CYR61/CCN1, in contrast, promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts [31]. The gene discussed is CCN1; the disease is Hepatic fibrosis.