IFNG and COVID-19: Furthermore, in COVID-19 therapy, ruxolitinib (Henan DaKen Chemical Co., Ltd., Zhengzhou, China), a JAK-STAT antagonist that inhibits IFN-gamma, is being used [154,155], and TNF-suppressing antibodies such as adalimumab and golimumab were also employed to manage COVID-19 cases with severe immune response [156].