The role of miR-19a has also been investigated in clear cell renal cell carcinoma (ccRCC) tissues and human cell lines, highlighting that the high expression of miR-19a-3p is correlated with poor prognosis via promoting cell proliferation and suppressing PTEN/mothers against decapentaplegic homolog 4 (SMAD4) expression [75]. This evidence concerns the gene SMAD4 and nonpapillary renal cell carcinoma.