The present study, therefore, aimed to determine: (a) the activation of OX-6 (major histocompatibility complex II) positive cells on CP following the intracerebroventricular (icv) injection of Prx2; and (b) the effects of clodronate liposomes on the hydrocephalus development induced by Prx2. The gene discussed is PRDX2; the disease is Hydrocephalus.