The database analysis also provided that the overall survival time of CCA patients with a high APEX1 level (Log Rank p < 0.0001; Figure 7G), and also with a high CDC42 level (Log Rank p < 0.0001; Figure 7H), was significantly shorter than those of having lower APEX1 or CDC42 levels. This evidence concerns the gene CDC42 and cholangiocarcinoma.