On the one hand, it has been established that hypoxia, by stabilization of the transcription factors hypoxia-inducible factors (HIFs), induces the expression of members of the lysyl oxidase (LOX) family, enzymes that catalyze the cross-linking of collagen molecules, which once secreted into the ECM are able to promote breast cancer metastasis [56]. This evidence concerns the gene LOX and breast carcinoma.