MMP14 and cancer: MMP-14 (a membrane-bound enzyme) is another important molecular component that allows the acquisition of a malignant phenotype by the proteolytic activation of soluble MMP-2 and -13, providing a clearer path for cancer cells to migrate by the proteolysis of a variety of ECM components (e.g.; gelatin, fibronectin, collagen) at pericellular sites, among other functions [35].