Loss of LGR4 also leads to abnormalities in the development of the anterior ocular segment, including microphthalmia, iris hypoplasia, iridocorneal angle malformation, corneal dysgenesis, and cataract produced by a diminution of Pitx2, a direct target of the Gpr48-mediated cAMP-CREB signaling pathway [56]. The gene discussed is LGR4; the disease is microphthalmia.