Deficiency of ACE2, which is involved in the modulation of the renin-angiotensin-aldosterone system (RAAS), is associated with an increase in the level of angiotensin 2, which leads to well-known adverse effects, such as hypertension, exudation, hypertrophy, fibrosis, and, subsequently, to a more severe course of infection. The gene discussed is ACE2; the disease is Hypertension.