The neuroprotective activity of ellagic acid has been also validated in APP/PS1 mice, a validated transgenic animal model of Alzheimer’s disease, where it prevents neuronal apoptosis in the hippocampus and rescues memory deficits through the inhibition of beta-amyloid production and tau hyperphosphorylation [57]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.