SOCS1 and idiopathic pulmonary fibrosis: Furthermore, independent analysis performed on a cohort of IPF and non-IPF patients using the Illumina Infinium Human Methylation 450 BeadChip microarray further validated our observations, showing that the SOCS1 gene is not constitutively methylated, and also demonstrated that there is no significant change in SOCS1 gene methylation in IPF compared to HLF (summarized in Table 2).