Although we could not confirm a diagnostic relevance for any of these circRNA, they have been associated with oncogenic functions in cancer in former studies: circSCARB1 promoted RCC progression by sequestering miR-510-5p and indirectly up-regulating SDC3 expression [22], and circCOL5A1 acted as a miR-1224-5p sponge, thereby activating CREB1 expression and promoting cellular proliferation in bladder cancer [23]. This evidence concerns the gene CREB1 and cancer.