In the domain of multimodality-imaging, various effective endoglin-targeting nanoparticles in the context of the 4T1 breast cancer mouse model have been reported, including (i) small copper sulfide nanoparticles (NIRF absorption and extinction properties), surrounded by mesoporous silica nanoshells and labeled with TRC105 and 64Cu, (ii) hMSNs, loaded with doxorubicin and ZW800 and conjugated with TRC105 and 64Cu, and (iii) red fluorescent zinc oxide nanoparticles conjugated with 64Cu and TRC105 [110,111,112]. This evidence concerns the gene ENG and breast carcinoma.