Shelled nanoprobes consisting of the CD105-specific peptide CL 1555 (amino acid sequence: AHKHVHHVPVRL), a poly(ε-caprolactone)-block-poly(ethylene glycol) amphiphilic copolymer, and a core comprising manganese ferrite (MnFe2O4) nanoparticles, were able to induce high contrast MR imaging of tumor vascular endothelial cells in vitro [83]. This evidence concerns the gene ENG and neoplasm.