A study found that obese patients in the highest BMI quartile (BMI: 40.3–61.2 kg/m2) had significantly higher CRP levels (4.83 μg/mL vs. 3.03 μg/mL; p = 0.033) and higher leptin levels (44.97 ng/mL vs. 24.64 ng/mL; p = 0.042) than patients in the lower quartile of BMI (BMI, 28.6–32.4) with heart failure, type 2 diabetes mellitus, and MetS [32]. This evidence concerns the gene LEP and heart failure.