In addition, they led us to consider that further studies on the correlation between MMP-7 and MMP-14 and their inhibitors TIMP-1 and TIMP-2, respectively, based on double staining, as well as eventually others (of proliferation and/or apoptosis) and also of MMP-14 with TIMP-2, may be of interest in the context of the relationship between IBD and CRC. The gene discussed is TIMP2; the disease is colorectal carcinoma.