TIMP1 and colorectal carcinoma: However, our results showed that MMP-14 was more frequently expressed by fibroblasts and MICs of inflamed tissues from CD patients with CRC development than from CD patients without CRC development (p = 0.028 and p = 0.036, respectively), whereas TIMP-1 was more frequently expressed by fibroblasts from CD patients with CRC development (p = 0.05) (Table 4).