TIMP1 and colorectal carcinoma: However, we found that MMP-7 and MMP-14 were more frequently expressed by fibroblasts from non-inflamed tissues of CD patients with CRC development than those of CD patients without CRC development (p < 0.01 and p < 0.05, respectively) (Table 5), whereas MMP-14 and TIMP-1 were more frequently expressed by MICs from non-inflamed tissues of CD patients with CRC development than those of CD patients without CRC development (p < 0.05 and p < 0.01, respectively).