Multiple factors secreted from cancer or stromal cells, such as macrophage colony-stimulating factor, granulocyte colony-stimulating factor (G-CSF), granulocyte monocyte colony-stimulating factor, vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF-β), tumor necrosis factor-alpha, prostaglandin E2 (PGE2), interleukins (IL-1β, IL-10, IL-4, and IL-6), and noncoding RNAs (microRNAs and long noncoding RNAs) are involved in these processes [4,8,10]. The gene discussed is IL6; the disease is cancer.